Jose Altuve led off the game with a home run, rookie Luis Garcia earned his fifth straight win and the Houston Astros beat Toronto 6-3 Sunday, finishing the Blue Jays' first homestand of the season in Buffalo.
Chas McCormick also homered, Yuli Gurriel had three hits and Alex Bregman scored twice as Houston won for the sixth time in eight games.
The Blue Jays went 3-2 to open their residency at the home of their Triple-A affiliate.
Toronto was 10-11 while hosting home games at its spring training site in Dunedin, Florida, to begin the year.
Garcia (5-3). battling a cold which limited him to 79 pitches, allowed one run and three hits in six innings.
The left-hander struck out eight, raising his season total to 68 to tie for the lead among American League rookies with Detroit's Tarik Skubal.